Introduction: Evidences show that parental morphine addiction impairs CNS development, learning and memory in offsprings. Regarding the role of glutamate in dentate gyrus on learning and memory, in this study the effect of parental morphine addiction on extracellular glutamate concentration of dentate gyrus was assessed. Materials and methods: In this study 20 female and 8 male rats were addic...

The present study investigated the effects of intra-dentate gyrus microinjection of naloxone (an opioid antagonist) and thioperamide (an antagonist of histamine H3 receptors) in the formalin test in rats. Subcutaneous injection of formalin (50 μl, 2.5 %) in the ventral surface of right hind paw produced a biphasic pattern (first phase: 0-5 min and second phase: 15 - 60 min) of licking/biting an...

the present study investigated the effects of intra-dentate gyrus microinjection of naloxone (an opioid antagonist) and thioperamide (an antagonist of histamine h3 receptors) in the formalin test in rats. subcutaneous injection of formalin (50 μl, 2.5 %) in the ventral surface of right hind paw produced a biphasic pattern (first phase: 0-5 min and second phase: 15 - 60 min) of licking/biting an...

Hippocampus is a part of the brain that has an essential role in memory and learning. It is involved in many cognitive and behavioral phenomena, including the pattern separation process: the ability to distinguish patterns with very high similarity. The present study compared the models of pattern separation in the dentate gyrus of the hippocampus and aimed to investigate the significant cel...

young children with history of maternal stress during pregnancy suffer from several neurological and psychological disorders in the childhood. the purpose of this study was to investigate the effect of maternal stress during pregnancy on the neural apoptosis in the newborns. pregnant wistar rats were divided into control and stress groups. stress was applied on the pregnant females from day 15 ...

neurogenesis occurs throughout life in several regions of the brain. in this lecture, a new sight for the role of the dentate gyrus and adult hippocampal neurogenesis in anxiety disorders will be discussed. the region that has obtained the most attention for its involvement in the neurogenesis of affective and anxiety disorders are the hippocampal and dentate gyrus. evidence strongly suggests t...

the dentate gyrus of hippocampus has long been considered as a focal point for studies on mechanisms responsible for the development of temporal lobe epilepsy (tle). change in intrinsic properties of dentate gyrus granule cells (gcs) has been considered as an important factor responsible in temporal lobe seizures. in this study, we evaluated the intrinsic properties of gcs, during acute phase o...

background and objectives: hippocampal volume reduction has been reported in diabetes mellitus type 1. it is believed that hyperglycemia and oxidative stress mediate neuropathological changes in hippocampal neurons. in this study we aimed to study the effect of insulin and an antioxidant like ascorbic acid on preventing volume changes of dentate gyrus and ca3 region of hippocampus. materials an...